Which are the 2 most common inherited metabolic diseases?
Which are the 2 most common inherited metabolic diseases?
Examples include:
- Maple syrup urine disease.
- Metachromatic leukodystrophy.
- Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS)
- Niemann-Pick.
- Phenylketonuria (PKU)
- Porphyria.
- Tay-Sachs disease.
- Wilson’s disease.
Why do consanguineous relationships increase the risk of a child being affected by a genetic disorder?
The offspring of consanguineous unions may be at increased risk for recessive disorders because of the expression of autosomal recessive gene mutations inherited from a common ancestor.
What is the danger of consanguineous marriage?
A recent study conducted in Saudi Arabia, where the practice is still common, shows that women there have a higher awareness of these risks compared to men. Consanguineous marriage can result in children with cognitive difficulties, heart defects, and impaired hearing, as well as other genetically inherited diseases.
What are the five countries with the highest incidence of consanguineous marriages?
The highest rates of consanguineous marriage occur in north and sub-Saharan Africa, the Middle East, and west, central, and south Asia.
Why close relative marriages are now discouraged?
Marrying within a family can lead to abnormalities in your future offspring. Now when you marry someone within your family, this gene pool will further become dense with recessive genes, due to both your genes getting added to the pool, making the possibility of your children having genetic abnormalities very high.
How is consanguineous marriage related to genetic diseases?
In conclusion, consanguineous marriage is significantly higher in many genetic diseases which suggests that couples may have deleterious lethal genes, inherited from common ancestor and when transmitted to their offsprings, they can lead to prenatal, neonatal, child morbidity or mortality.
What does it mean to be in a consanguineous marriage?
Consanguineous marriages, Non-consanguineous marriage, Congenital anomalies, Pedigree. Consanguineous marriage is referred to a marital union among close biological kin. In clinical genetics, it is called the relationship by marriage between first and second cousins [1].
What kind of diseases do consanguineous parents have?
The current generation of consanguineous parents had a slightly higher risk for diseases such as diabetes mellitus, cancer, blood and mental disorders, heart diseases, asthma, gastro-intestinal disorders, hypertension, hearing deficit, G6PD and common eye diseases.
How is consanguineous marriage related to mental retardation?
Consanguineous marriage was recorded in 51.5% of our cases with autosomal dominant diseases and in 31% of cases with X linked diseases, all cases of mental retardation (100%) and in 92.6% of patients with limb anomalies ( P < 0.001).
In conclusion, consanguineous marriage is significantly higher in many genetic diseases which suggests that couples may have deleterious lethal genes, inherited from common ancestor and when transmitted to their offsprings, they can lead to prenatal, neonatal, child morbidity or mortality.
Consanguineous marriages, Non-consanguineous marriage, Congenital anomalies, Pedigree. Consanguineous marriage is referred to a marital union among close biological kin. In clinical genetics, it is called the relationship by marriage between first and second cousins [1].
Consanguineous marriage was recorded in 51.5% of our cases with autosomal dominant diseases and in 31% of cases with X linked diseases, all cases of mental retardation (100%) and in 92.6% of patients with limb anomalies ( P < 0.001).
What are the risks of having a consanguineous parent?
The offsprings of consanguineous parents are at a risk of a host of disease like cancer, mental disorders, hypertension, hearing deficit, diabetes mellitus, epilepsy, asthma, leukemia, beta thalassemia, congenital and noncongenital heart diseases.