What is the cytomorphology of low grade fibromyxoid sarcoma?
What is the cytomorphology of low grade fibromyxoid sarcoma?
CYTOMORPHOLOGY OF LOW-GRADE FIBROMYXOID SARCOMA: Histologically, low-grade fibromyxoid sarcoma has a characteristic whorled arrangement of bland spindle cells with alternating areas of myxoid and collagenous stroma, but the cytologic findings, described in only a few case reports, 63–65 are somewhat non-specific.
How to tell if a tumor is myxoid or fibromyxoid?
The tumor typically exhibits alternating hypo- and hypercellular areas. Although the former tends to show a more fibrous stroma, the later is more myxoid. Delicate, arcading vessels are also typical, and occasional giant, fibroblastic rosettes can be seen.
When does a fibromyxoid sarcoma tumor go back?
The tumor has low risk for metastasis and recurrence in the first 5 years following the surgical removal of the main tumor. The rate of metastasis and recurrence is 5% and 10% respectively during this period However, with time, the incidence of both metastasis and recurrence increased.
Which is the most common type of stromal cell?
The most common stromal cells include fibroblasts and pericytes . The interaction between stromal cells and tumor cells is known to play a major role in cancer growth and progression.
How is fibromyxoid sarcoma different from myxofibrosarcoma?
Low-grade fibromyxoid sarcoma, first described by Evans, is clinically, morphologically, and cytogenetically different from a low-grade myxofibrosarcoma.62 It affects mainly younger adults in the third to fifth decades and arises in the deep soft tissue of the thigh, inguinal region, shoulder, and perineum.
The tumor typically exhibits alternating hypo- and hypercellular areas. Although the former tends to show a more fibrous stroma, the later is more myxoid. Delicate, arcading vessels are also typical, and occasional giant, fibroblastic rosettes can be seen.
Is there a cure for low grade fibromyxoid sarcoma?
Low-Grade Fibromyxoid Sarcoma are mostly slow-growing and do not present pain, in most cases. Tumor recurrence and metastasis to the lungs may take place several years after initial treatment (including surgical removal) The treatment of choice for Low-Grade Fibromyxoid Sarcoma is a complete surgical excision.
Which is the most common site of fibromyxoid sarcoma?
In trunk and deep extremities (thigh most common site) of young to middle-aged adults (median age 34 years, range 3 – 78 years), also intrathoracic ( Hum Pathol 2008;39:623 )