What is protein electrophoresis blood test for?
What is protein electrophoresis blood test for?
Protein electrophoresis is used to identify and measure the presence of abnormal proteins, the absence of normal proteins, and/or to detect various protein electrophoresis patterns associated with certain conditions, as found in blood, urine or other body fluids.
What does it mean when M protein levels are high?
Finding M proteins in the blood or urine is usually a sign of disease. Their presence is associated most commonly with a type of cancer of the plasma cells called multiple myeloma.
What causes polyclonal Hypergammaglobulinemia?
Polyclonal hypergammaglobulinemia (PHGG) has historically been associated with a variety of conditions including liver disease,1 infections such as that by human immunodeficiency virus,2 hematologic disorders such as idiopathic neutropenia,3 nonhematologic malignancies, and autoimmune conditions such as Sjögren …
Can a monoclonal gammopathy cause polyclonal hypergammaglobulinemia?
A monoclonal gammopathy or B cell lymphoma may develop in patients with Castleman’s disease or Sjögrens syndrome. In common with other neoplasms, some malignant lymphomas and lymphoproliferativc disorders may be associated with polyclonal hypergammaglobulinemia.
What does hypergammaglobulinemia stand for in medical terms?
Hypergammaglobulinemia is a condition that is characterized by the increased levels of a certain immunoglobulin in the blood serum. The name of the disorder refers to an excess of proteins after serum protein electrophoresis (found in the gammaglobulin region).
What causes a polyclonal gammopathy result on serum protein?
Liver disease, autoimmune disease, chronic viral or bacterial infections and various malignancies may cause a polyclonal rise in the gamma fraction (see Table 2 below). Polyclonal pattern serum protein electrophoresis (SPEP). Table 2. Diseases Associated with a Polyclonal Gammopathy (Open Table in a new window) Dupree, Shandi.
When does polyclonal hypergammaglobulinemia occur in peripheral T cell leukemia?
While polyclonal hypergammaglobulinemia is uncommon in these conditions, it occurs in up to one-half the cases of peripheral T cell leukemia/lymphoma and chronic myelomonocvtic leukemia. Polyclonal hypergammaglobulinemia is common in patients with angioimmunoblastic lym-phadenopathy with dysproteinemia (AILD).
A monoclonal gammopathy or B cell lymphoma may develop in patients with Castleman’s disease or Sjögrens syndrome. In common with other neoplasms, some malignant lymphomas and lymphoproliferativc disorders may be associated with polyclonal hypergammaglobulinemia.
Which is a protein electrophoresis test for hypergammaglobulinemia?
Polyclonal Gammopathy Serum protein electrophoresis (SPEP) is a useful screening test in the evaluation of hypergammaglobulinemia. An elevated gamma globulin level can be suspected in the setting of a patient with an increased total protein, but decreased albumin (e.g. in a comprehensive metabolic profile – CMP).
Liver disease, autoimmune disease, chronic viral or bacterial infections and various malignancies may cause a polyclonal rise in the gamma fraction (see Table 2 below). Polyclonal pattern serum protein electrophoresis (SPEP). Table 2. Diseases Associated with a Polyclonal Gammopathy (Open Table in a new window) Dupree, Shandi.
While polyclonal hypergammaglobulinemia is uncommon in these conditions, it occurs in up to one-half the cases of peripheral T cell leukemia/lymphoma and chronic myelomonocvtic leukemia. Polyclonal hypergammaglobulinemia is common in patients with angioimmunoblastic lym-phadenopathy with dysproteinemia (AILD).