What is IgG infusion used for?
What is IgG infusion used for?
Uses. IVIg is used to reduce the effects of some inflammatory conditions that involve the immune system, also known as autoimmune diseases. It’s also used to increase levels of immunoglobulins if these are low, or have been lowered by treatment with other drugs, such as rituximab.
When do you give IVIG for low IgG?
Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.
How much does IgG infusion cost?
The total cost of IVIG therapy ranges from $5000 to $10,000, depending on the patient’s weight and number of infusions per course. Additional costs may include a hospital stay if home infusion is not covered.
What are side effects of IgG infusion?
One of the most common side effects is headache. Other side effects include chills, fever, flushing, flu-like muscle pains or joint pains, feeling tired, having nausea, vomiting, and rash.
What is the IgG level for hypogammaglobulinemia?
Hypogammaglobulinemia is defined as an IgG less than 2 standard deviations from normal, and agammaglobulinemia is usually defined as an IgG level less than 100 mg/dL.
What to do if you have hypogammaglobulinemia?
Treatment options. Doctors treat bacterial infections with antibiotics. People who get severe or frequent bacterial infections may need to take antibiotics for several months at a time to prevent them. If your hypogammaglobulinemia is severe, you may get immune globulin replacement therapy to replace what your body isn’t making.
How often should I take immune globulin infusions?
-Dose and dosing frequency may vary from patient to patient. -No optimum target serum IgG level has been determined. -Target a trough level of 600 mg/dL or higher of IgG; consider dose adjustments if trough IgG levels are less than 500 mg/dL. -Initial infusion rate is 0.5 mg/kg/min for 30 minutes.
Are there any side effects to chemotherapy for hypogammaglobulinemia?
Despite the hypogammaglobulinemia, most patients do not experience infectious complications prior to treatment with chemotherapy. Those who do, suffer recurrent sinopulmonary infections caused by bacteria that ravage patients with primary humoral immunodeficiency syndromes.
Hypogammaglobulinemia is defined as an IgG less than 2 standard deviations from normal, and agammaglobulinemia is usually defined as an IgG level less than 100 mg/dL.
How many patients develop hypogammaglobulinemia after rituximab use?
After rituximab use, hypogammaglobulinemia was identified in 38.54% of patients with initially normal SIgG. The risk was greater in patients who received maintenance rituximab. Symptomatic hypogammaglobulinemia that prompted IVIG administration developed in 6.6% of patients.
What should the infusion rate be for immune globulin?
Use: Prevention of bacterial infections in hypogammaglobulinemia and/or recurrent bacterial infections associated with B-cell chronic lymphocytic leukemia (CLL). -Initial infusion rate is 0.5 mg/kg/min for 30 minutes. -If initial infusion is tolerated, may increase to 1 mg/kg/min, and gradually increased step-wise as tolerated.
Treatment options. Doctors treat bacterial infections with antibiotics. People who get severe or frequent bacterial infections may need to take antibiotics for several months at a time to prevent them. If your hypogammaglobulinemia is severe, you may get immune globulin replacement therapy to replace what your body isn’t making.