What is chronic refractory ITP?
What is chronic refractory ITP?
Chronic refractory ITP may be defined as the failure of any modality to keep the platelet count above 20 × 109/L for an appreciable time without unacceptable toxicity.
How do you treat steroid refractory ITP?
For steroid-refractory ITP, there are several treatments, such as splenectomy, danazol, azathioprine, cyclophosphamide, cyclosporine, rituximab, and thrombopoietin (TPO) receptor agonists [2]. Splenectomy induces a durable complete response in approximately 70% of patients with steroid-refractory ITP.
Is it difficult to diagnose and treat Refractory ITP?
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment | Blood | American Society of Hematology In this timely review, Miltiadous and colleagues highlight the importance of precise diagnosis of refractory immune thrombocytopenia (ITP) and comprehensively s
What should I know about refractory immune thrombocytopenia?
Suggestions are otherwise based on our experience and opinions. What is refractory ITP?
What are the different types of ITP treatment?
ITP treatment may be conceptually divided into rescue therapy and maintenance therapy. The objective of rescue therapy is a swift rise in platelet count in a patient with active hemorrhage, a high risk for bleeding, or need for a critical procedure.
Can a patient with HRQOL be refractory to maintenance therapy?
Regarding patients refractory to maintenance therapy, we include not only patients who require treatment to mitigate bleeding risk after splenectomy but also patients who are unable or disinclined to undergo splenectomy and patients in whom the primary objective of treatment is improvement in HRQoL.
Which is the best treatment for chronic Refractory ITP?
Chronic refractory ITP may be defined as the failure of any modality to keep the platelet count above 20 × 10 9 /L for an appreciable time without unacceptable toxicity. High-dose cyclophosphamide has been described as effective therapy for ITP [ 4
How to define chronic refractory immune thrombocytopenia?
Chronic refractory ITP may be defined as the failure of any modality to keep the platelet count above 20 × 10 9 /L for an appreciable time without unacceptable toxicity.
Are there any new therapies for patients with ITP?
New agents for patients with ITP are currently in development that enhance plateletproduction,ratherthandiminishplateletdestruction.In preliminary reports, these agents have been effective in maintaining safe platelet counts in patients with chronic ITP that was refractory to splenectomy and other treatments.
Are there any randomized controlled studies for ITP?
Randomized controlled studies of common treatments and novel treatments for refractory patients are urgently needed. The management of immune thrombocytopenia (ITP) has significantly changed over the last 50 years with a better understanding of the disease and introduction of many steroid‐sparing agents.