What is a good substitute for losartan HCTZ?
What is a good substitute for losartan HCTZ?
Telmisartan
- Telmisartan, also available as brand-name Micardis, has better 24-hour coverage than losartan.
- Like the other ARBs, telmisartan comes in convenient combination tablets: telmisartan/HCTZ and telmisartan/amlodipine.
- Telmisartan is equally as effective as olmesartan at lowering blood pressure.
Why is losartan no longer available?
Losartan was recalled due to impurities found while testing finished products. The impurity found in these batches is N-Methylnitrosobutyric acid (NMBA). This is the third type of impurity to cause recalls of these medications. The other two are N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA).
What are the long term side effects of losartan HCTZ?
If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.
How much Hydrochlorothiazide is in Hyzaar 50 / 12.5 tablets?
HYZAAR is available for oral administration in three tablet combinations of losartan and hydrochlorothiazide. HYZAAR 50/12.5 contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. HYZAAR 100/12.5 contains 100 mg of losartan potassium and 12.5 mg of hydrochlorothiazide.
How is losartan used to treat renal insufficiency?
Losartan: Following oral administration, plasma concentrations and AUCs of losartan and its active metabolite are increased by 50-90% in patients with mild (creatinine clearance of 50 to 74 mL/min) or moderate (creatinine clearance 30 to 49 mL/min) renal insufficiency.
How is losartan converted to an active metabolite?
Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P450 enzymes. It is converted, in part, to an active carboxylic acid metabolite that is responsible for most of the angiotensin II receptor antagonism that follows losartan treatment.
How does Sandoz losartan work to lower blood pressure?
Losartan belongs to the class of medications called angiotensin II receptor blockers. They help to lower blood pressure by relaxing blood vessels. Hydrochlorothiazide belongs to the class of medications called diuretics or “water pills.”
How often can you take losartan and hydrochlorothiazide?
Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day
How is losartan used to treat high blood pressure?
Losartan is an angiotensin II receptor antagonist. Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Hydrochlorothiazide and losartan is a combination medicine used to treat high blood pressure (hypertension).
Is there a generic version of losartan available?
Losartan is available as a very affordable generic. Losartan is made as a stand-alone drug, and in a combination tablet with the diuretic, hydrochlorothiazide (HCTZ), as losartan/HCTZ.
What are the ingredients in losartan potassium and hydrochlorothiazide tablets?
What are the ingredients in Losartan Potassium and Hydrochlorothiazide tablets? Active ingredients: losartan potassium, hydrochlorothiazide. Inactive ingredients: microcrystalline cellulose, lactose monohydrate, pregelatinized starch, magnesium stearate, colloidal silicon dioxide, hydroxypropyl cellulose, hypromellose, and titanium dioxide.