What drugs can cause pancytopenia?
What drugs can cause pancytopenia?
Medications that can affect bone marrow function include chloramphenicol, chemotherapy drugs, thiazide diuretics, anti-epileptic drugs, colchicine, azathioprine, and non-steroidal anti-inflammatory drugs (NSAIDs). The list here covers just some of the potential disease-related pancytopenia causes.
What is the most common cause of pancytopenia?
Conclusion : This study concluded that most common cause of pancytopenia is Megaloblastic anemia, followed by acute myeloid leukemia and aplastic anemia. Bone marrow examination is a single useful investigation which reveals the underlying cause in patients with pancytopenia.
What drugs cause bone marrow suppression?
Other chemicals/drugs known to cause bone marrow suppression include chloramphenicol, meclofenamic acid, phenylbutazone, quinidine, trimethoprim-sulfadiazine, albendazole and fenbendazole (Manyan et al., 1972).
What is the criteria for pancytopenia?
Pancytopenia is defined as haemoglobin of < 9 gm/dl, WBC < 4,000/cmm, and platelets < 100,000/cmm. Severe pancytopenia is defined as absolute neutrophil count < 500/cmm, platelet count < 20,000/cmm, and corrected reticulocyte count < 1%.
What is pancytopenia a symptom of?
Pancytopenia occurs when a person has a decrease in all three blood cell types. This happens when something is wrong with the bone marrow, where blood cells are formed. Pancytopenia has many possible causes: Diseases such as cancer, lupus or bone marrow disorders. Infections.
What is the treatment for pancytopenia?
Treatments for pancytopenia include: drugs to stimulate blood cell production in your bone marrow. blood transfusions to replace red blood cells, white blood cells, and platelets. antibiotics to treat an infection.
Can a virus cause pancytopenia?
The second major cause of infectious pancytopenia is through the effect of viral infections. Essentially, any virus can cause suppression of multiple cell lines but the herpes viruses, including Epstein-Barr virus (EBV) and cytomegalovirus (CMV), as well as viral hepatitides are the most commonly implicated.
What disease causes bone marrow suppression?
If you have a blood-related cancer like multiple myeloma, your bone marrow may not be able to make enough blood cells. This is called myelosuppression or bone marrow suppression. It can also be a side effect of some cancer treatments, like radiation, chemotherapy drugs, and steroids.
What do you need to know about pancytopenia?
The treatment of pancytopenia depends on the cause. You may need any of the following: A blood transfusion can help increase red blood cell, white blood cell, and platelet levels.
Why do you need a blood transfusion for pancytopenia?
You may need any of the following: A blood transfusion can help increase red blood cell, white blood cell, and platelet levels. This may prevent bleeding or organ damage. This does not treat pancytopenia. Instead, a blood transfusion may keep you safe until the cause of pancytopenia is known.
How is a bone marrow biopsy used to treat pancytopenia?
A bone marrow biopsy is a procedure to remove a small amount of bone marrow from your bone. This procedure is used to check how well your bone marrow is making blood cells. The bone marrow sample is also checked for tumors or anything that prevents the bone marrow from making healthy cells. How is pancytopenia treated?
How is pancytopenia linked to an autoimmune disorder?
It may be linked to an autoimmune disorder, in which the body’s immune system attacks its own tissues as foreign substances, or an environmental contaminant. In rare cases, pregnancy can lead to autoimmune processes that may trigger pancytopenia.
The treatment of pancytopenia depends on the cause. You may need any of the following: A blood transfusion can help increase red blood cell, white blood cell, and platelet levels.
Are there any medications that can cause pancytopenia?
Examples could include: Medications that can affect bone marrow function include chloramphenicol, chemotherapy drugs, thiazide diuretics, anti-epileptic drugs, colchicine, azathioprine, and non-steroidal anti-inflammatory drugs (NSAIDs). The list here covers just some of the potential disease-related pancytopenia causes. Who is at risk?
You may need any of the following: A blood transfusion can help increase red blood cell, white blood cell, and platelet levels. This may prevent bleeding or organ damage. This does not treat pancytopenia. Instead, a blood transfusion may keep you safe until the cause of pancytopenia is known.
A bone marrow biopsy is a procedure to remove a small amount of bone marrow from your bone. This procedure is used to check how well your bone marrow is making blood cells. The bone marrow sample is also checked for tumors or anything that prevents the bone marrow from making healthy cells. How is pancytopenia treated?