Recommendations / 01/12/2019

What does Sandostatin do for acromegaly?

Sandostatin substantially reduces growth hormone and/or IGF-I (somatomedin C) levels in patients with acromegaly. Single doses of Sandostatin have been shown to inhibit gallbladder contractility and to decrease bile secretion in normal volunteers.

Is octreotide used for acromegaly?

Twelve months of treatment with octreotide LAR results in similar biochemical control to that seen after surgery. Octreotide is the most widely used medical treatment for acromegaly; it is effective in more than 50% of cases, is well tolerated and has high compliance rates based on monthly intramuscular injections.

Why is octreotide used in acromegaly?

The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce pituitary tumor shrinkage.

What does Lar stand for in Sandostatin LAR?

Depot long-acting somatostatin analog (Sandostatin-LAR) is an effective treatment for acromegaly. J Clin Endocrinol Metab. 1995 Nov;80(11):3267-72.

Does Sandostatin shrink tumors?

Somatostatin analogs Sometimes octreotide can temporarily shrink carcinoid tumors, but it does not cure them. The original version of octreotide (Sandostatin®) is injected under the skin (subcutaneously) at least twice daily. Some people learn to give this injection themselves at home.

How long can you take Sandostatin?

Immediate-release Sandostatin This dose is given for at least 2 weeks. The maximum recommended dosage is 750 mcg a day. Your doctor may give you a different dosage depending on several factors, including your age and whether you have kidney disease.

What are the side effects of octreotide?

Octreotide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

diarrhea.
constipation.
pale, bulky, foul-smelling stools.
constantly feeling the need to empty the bowels.
gas.
stomach pain.
nausea.
heartburn.

How does somatostatin treat acromegaly?

The most extensively studied and used somatostatin analogue, octreotide, binds to the somatostatin receptor subtypes II and V, inhibiting GH secretion. Octreotide suppresses the serum GH level to less than 2.5 mcg/L in 65% of patients with acromegaly and normalizes circulating IGF-I levels in 70% of patients.

Is Sandostatin LAR a chemo drug?

In some cases, health care professionals may use the trade name sandostatin or other names sandostatin LAR or octreotide acetate when referring to the generic drug name octreotide. Drug type: Octreotide is hormone drug that is used to treat some types of cancer. This medication is classified as a somatostatin analog.

How effective is Sandostatin?

Immediate-release Sandostatin was effective for lowering the average monthly growth hormone levels to less than: 5 nanograms per milliliter (ng/mL) in 78% to 95% of adults who used the drug. 2.5 ng/mL in 50% to 69% of adults who used the drug. 1 ng/mL in 7% to 21% of adults who used the drug.

Does Sandostatin cause weight gain?

low blood sugar–headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or. underactive thyroid–extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain.

Can octreotide cause hair loss?

We used octreotide to treat a woman with acromegaly and observed pituitary adenoma shrinkage after 5 months. Diffuse scalp hair loss occurred after 5 months, resulting in the discontinuation of treatment. After the cessation of octreotide, the hair loss stopped and hair growth resumed.

Where to get a Sandostatin injection for acromegaly?

If you are new to Sandostatin LAR Depot, your first dose must be received in your doctor’s office Receive Sandostatin (octreotide acetate) injections at convenient locations. When you’re dealing with acromegaly, this program offers a convenient administration option Your Sandostatin, your schedule.

When to use Sandostatin Lar depot for injectable suspension?

Sandostatin ® LAR Depot (octreotide acetate) for injectable suspension is indicated for patients in whom initial treatment with immediate-release Sandostatin ® (octreotide acetate) Injection has been shown to be effective and tolerated for.

Is there a mobile Administration program for Sandostatin?

As a patient receiving Sandostatin ® LAR Depot (octreotide acetate for injectable suspension) therapy, you know how important it is to keep to your regularly scheduled appointments and get your injections exactly as prescribed. That’s why the Mobile Administration Program (MAP) was developed—to make coordinating your treatment a little easier.

Which is better Sandostatin Lar or immedi-ate-release?

The relative bioavailability of the long-acting release Sandostatin LAR®Depot compared to immedi- ate-release Sandostatin®Injection solution given subcutaneously was 60%-63%. In patients with acromegaly, the octreotide concentrations after single doses of 10 mg, 20 mg and 30 mg Sandostatin LAR®Depot were dose proportional.

What kind of acetate is in Sandostatin lardepot?

Sandostatin LAR®Depot (octreotide acetate for injectable suspension) is a long-acting dosage form consisting of microspheres of the biodegradable glucose star polymer, D,L-lactic and glycolic acids copolymer, containing octreotide.