Recommendations / 21/06/2021

Is there an algorithm for workup of thrombocytopenia?

Figure 1. Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. Figure 1. Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film.

How is the peripheral blood film used to diagnose thrombocytopenia?

The presence of an ischemic limb of skin necrosis should raise suspicion of heparin-induced thrombocytopenia (HIT). In the era of genomic medicine and widespread molecular testing, examination of the peripheral blood film still remains the most important investigation guiding our diagnostic approach to thrombocytopenia ( Figure 1 ).

How is the reticulocyte count used to diagnose anaemia?

This is the main method used to classify anaemia.  Reticulocyte count: concentration of immature red blood cells – increased in blood loss and haemolytic anaemia because the bone marrow works harder to replace lost cells. Red cell count (RCC) : the concentration of the red blood cells within the blood. 

Which is the correct interpretation of the full blood count?

© 2013 Dr Christopher Mansbridge at www.OSCEstop.com, a source of free OSCE exam notes for medical students’ finals OSCE revision Interpretation of the Full Blood Count Red Blood Cells Constituents of the red cell count Haemoglobin (Hb) concentration of haemoglobin within the blood.

What are the sequelae of lymphocytopenia blood test?

Sequelae include opportunistic infections and an increased risk of malignant and autoimmune disorders. If the complete blood count reveals lymphocytopenia, testing for immunodeficiency and analysis of lymphocyte subpopulations should follow.

How are blood tests used to diagnose anaemia?

Often the results of these tests will trigger further testing. For example, the presence of anaemia will usually lead to testing for iron deficiency, possibly vitamin B12 and folate, screening for haemolysis (destruction of red blood cells) and a measure of how well the bone marrow, which makes red blood cells, is responding.