Is breast cancer hereditary from grandparents?
Is breast cancer hereditary from grandparents?
You are substantially more likely to have a genetic mutation linked to breast cancer if: You have blood relatives (grandmothers, mother, sisters, aunts) on either your mother’s or father’s side of the family who had breast cancer diagnosed before age 50.
What are the risks of having a grandmother with breast cancer?
One Swedish study reported that having a grandmother with breast cancer was associated with similar excess breast cancer risk (1.27 times the normal risk) as having an affected half sister (1.26) for maternal relatives.
How does family history affect risk of breast cancer?
On the other hand, daughters of mothers who were diagnosed at age 82 and older reached the level of risk of women aged 50 without a family history approximately 3.3 years earlier. Having a sister with breast cancer confers a similar or slightly higher risk of breast cancer as having a mother with breast cancer.
Why is Dad’s Side important in breast cancer history?
Dad’s Side Important in Breast Cancer History. Women who carry these genetic mutations face a 55% to 87% increased lifetime risk of breast cancer and a 20% to 44% increased lifetime risk of ovarian cancer. Both men and women who carry the BRCA1 and BRCA2 genes have the same 50% risk of passing these genetic mutations on to their children.
How does having a brother with breast cancer affect your risk?
However, having a brother with breast cancer increases breast cancer risk compared to having a sister with breast cancer. The Swedish study mentioned above found that the relative risk for a woman increased 2.48 times when a brother had breast cancer compared to 1.87 when a sister was affected.
One Swedish study reported that having a grandmother with breast cancer was associated with similar excess breast cancer risk (1.27 times the normal risk) as having an affected half sister (1.26) for maternal relatives.
Can a family history of breast cancer lead to breast cancer?
In some cases, a strong family history of breast cancer is linked to having an abnormal gene associated with a high risk of breast cancer, such as the BRCA1 or BRCA2 gene. In other cases, an abnormal CHEK2 gene may play a role in developing breast cancer. Steps you can take
Is it possible to get breast cancer from a father?
This could mean that doctors aren’t recognizing that paternal (father’s) family history of breast and ovarian cancer is equally important as maternal (mother’s) family history when considering abnormal breast cancer gene risk.
Why is fathers side of family important in breast cancer history?
“With an increased awareness by healthcare providers of the potential paternal transmission of BRCA1 and BRCA2 gene mutations, together with their ability to provide accurate risk assessments, fewer opportunities for cancer prevention will be missed,” McCaiug and her team write.