Is acinic cell carcinoma dangerous?
Is acinic cell carcinoma dangerous?
Acinic cell carcinoma is a rare salivary neoplasm that is generally associated with a good prognosis, although a subset of patients develops local and distant recurrences.
Does acinic cell carcinoma spread?
Although acinic cell carcinomas rarely metastasize, they have a high tendency to recur locally if they are incompletely excised. We describe a patient with acinic cell tumor arising in the parotid gland, with metastases to the contralateral orbit, submandibular salivary gland, and submandibular lymph node.
Can you die from acinic cell carcinoma?
Most of the 13 deaths (8.4%) were due to the development of distant metastases. The mean time from disease to death was 3.8 years. “There is a subset of patients, including those with large tumors and patients over the age of 45, whose prognosis is less favorable.
Is parotid cancer aggressive?
No patients had recurrence or distant metastasis after 5 disease-free years. Conclusions and Relevance Salivary duct carcinoma is an aggressive disease.
Can acinic cell carcinoma be cured?
The 10-year cumulative survival rate was 90.9% with a mean follow-up of 111 months, ranging 17-251 months. The 10-year disease free survival rate was 74.2% and the mean duration of recurrence from initial surgery was 92.3 months (Fig. 1). 10-year disease free survival of parotid acinic cell carcinoma patients.
What type of cancer is acinic cell carcinoma?
Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men.
What are carcinoma cells?
Carcinoma is a type of cancer that starts in cells that make up the skin or the tissue lining organs, such as the liver or kidneys. Like other types of cancer, carcinomas are abnormal cells that divide without control. They are able to spread to other parts of the body, but don’t always.
What kind of cancer is acinic cell carcinoma?
Acinic Cell Carcinoma is a rare malignancy accounting for 1 to 6% of all salivary gland tumors and 15% of all malignant tumors in parotid gland. Most acinic cell carcinomas start in the parotid gland. They tend to be slow growing and mainly occur at a younger age than most other salivary gland cancers.
Which is worse acinic cell carcinoma or high grade transformation?
Patients with acinic cell carcinomas with high grade transformation (sometimes also called dedifferentiation) have significantly worse survival.
Is there such a thing as an acinar cell carcinoma?
Acinar cell carcinoma is rare, only about 1% of all pancreatic cancers. It occurs at any age, including in pediatric patients. Rarely, the tumor may release digestive enzymes, resulting in disseminated fat necrosis, polyarthralgia, and eosinophilia. Histologic examination shows atypical acinar cells forming acinar or trabecular patterns. 157
What is the prognosis for acinic cell carcinoma?
Micrograph of acinic cell carcinoma. Pap stain. Fine needle aspiration specimen. Prognosis is good for acinic cell carcinoma of the parotid gland, with five-year survival rates approaching 90%, and 20-year survival exceeding 50%.
Which is more aggressive prostate cancer or acinar adenocarcinoma?
It is a more aggressive prostate cancer than acinar adenocarcinoma and is usually given a Gleason score of at least 4. There are even rarer forms of adenocarcinoma, including mucinous (colloid) carcinoma, cribriform carcinoma, squamous cell cancer, sarcomatoid carcinoma, carcinosarcoma, and prostate duct adenocarcinoma, or PDA.
What kind of cancer is acinar cell carcinoma?
These tumors, which resemble serous acinar cells, vary in their behavior from locally aggressive to blatantly malignant. It can also appear in the breast. The pancreatic form of acinic cell carcinoma is a rare subtype of exocrine pancreatic cancer.
Is there such a thing as acinic cell carcinoma?
Acinic cell carcinoma appears in all age groups, but presents at a younger median age (approx. 52 years) than most other salivary gland cancers. Occurrences in children are quite common. Acinic cell carcinoma of the lung is a very rare variant of lung cancer that, in this organ, is classified among the salivary gland-like carcinoma of the lung.
Patients with acinic cell carcinomas with high grade transformation (sometimes also called dedifferentiation) have significantly worse survival.