How is the release of TSH regulated?
How is the release of TSH regulated?
The hypothalamic-pituitary axis regulates TSH release through hypothalamic neurons that secrete thyroid releasing hormone (TRH), a hormone that stimulates thyrotrophs in the anterior pituitary to secrete TSH.
How does TSH induce immediate release of thyroid hormone?
TSH induces immediate release of thyroid hormone by activating every step involved in Thyroid Hormone Synthesis but most importantly induces endocytosis of peroxidase-processed thyroglobulin.
How does TSH act as a trophic factor?
Thyroid Hormone Regulation. TSH induces immediate release of thyroid hormone by activating every step involved in Thyroid Hormone Synthesis but most importantly induces endocytosis of peroxidase-processed thyroglobulin. TSH improves long-term capacity of the thyroid gland to produce thyroid hormones by acting as a trophic factor,…
What does TSH do to the human body?
TSH (with a half life of about an hour) stimulates the thyroid gland to secrete the hormone thyroxine (T4), which has only a slight effect on metabolism.
Where does a TSH blood test take place?
A TSH test is a blood test that measures this hormone. The thyroid is a small, butterfly-shaped gland located near your throat. Your thyroid makes hormones that regulate the way your body uses energy.
What causes low levels of TSH?
Causes. Low TSH is caused by conditions that increase thyroxine production such as Graves’ disease, thyroiditis, and thyroid nodules, which are benign tumors symptomatic of Plummer’s disease and goiter.
What does decreased TSH mean?
Low TSH refers to abnormally low levels of thyroid stimulating hormone in the bloodstream, potentially resulting from an array of conditions and causing a condition known as hyperthyroidism .
What are the symptoms of high TSH?
The list of common symptoms of high TSH levels includes weakness, fatigue, difficulty waking up, difficulty losing weight and/or weight gain, roughening of the hair and skin, hair loss, a pale or yellow tinge to skin, brittle nails, intolerance to cold, constipation, depression, mood swings, abnormal menstruation, decreased sex drive and memory loss.
What are the normal levels of TSH?
The typical range of reference for TSH levels is anywhere between 0.4 and 4.9 milliunits per liter (mU/L). A recent study suggests that the normal range should be more like 0.45 to 4.12 mU/L. TSH can vary wildly based on your age, sex, and stage of life.