How is follicular lymphoma treated?
How is follicular lymphoma treated?
FL is generally very responsive to radiation and chemotherapy. Radiation alone can provide a long-lasting remission in some patients with limited disease. In more advanced stages, physicians may use one or more chemotherapy drugs or the monoclonal antibody rituximab (Rituxan), alone or in combination with other agents.
How is late relapsed follicular lymphoma treated?
Chemotherapy, radiation, monoclonal antibodies, and chimeric antigen receptor (CAR) T cell therapy may be used to treat relapsed/refractory FL. Common second-line regimens include: Axicabtagene ciloleucel (Yescarta) Bendamustine (Treanda) with or without rituximab (Rituxan) or obinutuzumab (Gazyva)
Is follicular lymphoma cancer curable?
Follicular lymphoma is usually not considered to be curable, but more of a chronic disease. Patients can live for many years with this form of lymphoma.
Are there any early treatment options for follicular lymphoma?
Observation continues to be appropriate for asymptomatic patients with low bulk disease and no cytopenias. There is no overall survival advantage for early treatment with either chemotherapy or single agent rituximab. For patients needing therapy, most patients are treated with chemoimmunotherapy, w …
Is there an overall survival advantage for follicular lymphoma?
There is no overall survival advantage for early treatment with either chemotherapy or single agent rituximab. For patients needing therapy, most patients are treated with chemoimmunotherapy, w … Observation continues to be appropriate for asymptomatic patients with low bulk disease and no cytopenias.
What kind of disease is follicular lymphoma?
Abstract Disease overview: Follicular lymphoma (FL) is generally an indolent B cell lymphoproliferative disorder of transformed follicular center B cells. Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, and splenomegaly. Extranodal involvement is less common.
Who are the authors of the follicular lymphoma report?
Am J Hematol. 2020 Mar;95(3):316-327.doi: 10.1002/ajh.25696. Epub 2019 Dec 22. Authors Arnold Freedman 1 , Eric Jacobsen 1
Observation continues to be appropriate for asymptomatic patients with low bulk disease and no cytopenias. There is no overall survival advantage for early treatment with either chemotherapy or single agent rituximab. For patients needing therapy, most patients are treated with chemoimmunotherapy, w …
How to determine the survival rate of follicular lymphoma?
Buske C et al. The Follicular Lymphoma International Prognostic Index (FLIPI) separates high-risk from intermediate- or low- risk patients with advanced-stage follicular lymphoma treated front-line with rituximab and the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with respect to treatment outcome.
What are the symptoms of follicular lymphoma?
Follicular lymphoma is characterized by diffuse lymphadenopathy, bone marrow involvement, and splenomegaly. Extranodal involvement is less common. Cytopenias are relatively common but constitutional symptoms of fever, night sweats, and weight loss are uncommon in the absence of transformation to diffuse large B cell lymphoma.
How is the Flipi used to diagnose follicular lymphoma?
The Follicular Lymphoma International Prognostic Index (FLIPI) separates high-risk from intermediate- or low- risk patients with advanced-stage follicular lymphoma treated front-line with rituximab and the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with respect to treatment outcome.