Does Imuran affect male fertility?
Does Imuran affect male fertility?
Azathioprine does not reduce semen quality and, therefore, does not affect fertility in male IBD patients.
Does Imuran affect fertility?
There is little published data in women, but azathioprine does not seem to have detrimental effects on fertility. The AMH concentrations of patients treated with azathioprine, mycophenolate or calcineurin inhibitors for lupus were not lower than in the control population [19].
Does azathioprine cause birth defects?
Conclusions: Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular/atrial septal defects. There is also an increased risk of growth restriction and preterm delivery.
Does Imuran lower sperm count?
With regard to fathers taking thiopurines, one study suggests azathioprine and mercaptopurine do not reduce sperm quality, but some manufacturers say mercaptopurine may occasionally cause temporary reductions in sperm counts.
Do immunosuppressants cause infertility?
It is known that immunosuppressive drugs can affect male sexual health and reproduction via multiple mechanisms: by altering reproductive hormone secretion and/or action, by disrupting spermatogenesis or sperm motility and by causing sexual dysfunction (Sasaki et al., 2011).
Can you breastfeed while taking Imuran?
The World Health Organization (WHO) and Food and Drugs Administration advises against the use of azathioprine in breastfeeding women due to its immunosuppressive effect on babies. Recent studies suggest that azathioprine in doses (1.2–2.1 mg/kg) may be safe in breastfeeding women.
Can azathioprine stop you getting pregnant?
There’s no clear evidence to suggest that taking azathioprine will reduce fertility in either men or women. However, speak to your doctor if you are pregnant or trying for a baby.
Is it safe to take azathioprine while pregnant?
Azathioprine and pregnancy If you become pregnant, do not stop taking your medicine and speak to your doctor. They’ll review your treatment and tell you if it’s OK to keep taking azathioprine. In most cases, it’s safe to take during pregnancy.
Does hydroxychloroquine affect male fertility?
This antimalarial drug is used either alone or in combination with other DMARDs in rheumatoid arthritis. It is also used to prevent flares in patients with SLE. Fertility and Conception. There are no reports of adverse effects of hydroxychloroquine on fertility.
What kind of cancer can you get from Imuran?
Imuran may cause a rare type of lymphoma (cancer) of the liver, spleen, and bone marrow that can be fatal. This has occurred mainly in teenagers and young men with Crohn’s disease or ulcerative colitis. You should not take Imuran if you are allergic to Imuran. You should not use Imuran to treat rheumatoid arthritis if you are pregnant.
When to tell your doctor about Imuran side effects?
Keep using Imuran as directed and tell your doctor if your symptoms have not improved after 12 weeks of use. Take with food if Imuran upsets your stomach. You may not be able to continue taking other arthritis medications together with Imuran. Do not change your dose or dosing schedule without your doctor’s advice.
Can you take Imuran with other arthritis medications?
Take Imuran with food to lessen stomach upset. You may not be able to continue taking other arthritis medications together with Imuran. Follow your doctor’s dosing instructions very carefully. Imuran can lower blood cells that help your body fight infections and help your blood to clot.
Can a brain infection from Imuran cause death?
Imuran may cause a serious brain infection that can lead to disability or death. Call your doctor right away if you have problems with speech, thought, vision, or muscle movement. These symptoms may start gradually and get worse quickly. Stop using Imuran and call your doctor right away if you have any of these symptoms of lymphoma: