Does Crestor have a grapefruit warning?
Does Crestor have a grapefruit warning?
Some statins (cholesterol-lowering drugs): lovastatin (Mevacor), atorvastatin (Lipitor), simvastatin (Zocor). (Other statins such as fluvastatin (Lescol), pravastatin (Pravachol), and rosuvastatin (Crestor) have little or no interaction with grapefruit juice.)
Is Crestor made by AstraZeneca?
AstraZeneca will continue to manufacture and supply Crestor to Grünenthal during a transition period. AstraZeneca will also continue selling the medicine in other countries, including those in North America, in Japan, China and other emerging markets.
Which is better Lipitor or CRESTOR?
The study concluded that Crestor lowered LDL cholesterol by 8.2% more than Lipitor, and Crestor lowered total cholesterol significantly more than all the other statins studied. Crestor also increased HDL cholesterol (the good kind of cholesterol) more than Lipitor did.
Is CRESTOR being taken off the market?
Despite the end of the era for Crestor, one branded statin remains available in the United States. Pitavastatin (Livalo, Kowa Pharmaceuticals), available in Japan since 2003 and in the US since 2009, is approved for the treatment of elevated cholesterol levels and is considered a “modest” LDL lowering drug.
Are there any lawsuits against AstraZeneca over Crestor?
Those lawsuits have all been dismissed, withdrawn or quietly settled. AstraZeneca agreed to pay $110 million to resolve a Texas whistleblower lawsuit about false and misleading marketing of Crestor and another drug under a settlement announced in August 2018.
Who are the rights holders of Crestor in the UK?
AstraZeneca has completed the divestment of the rights to Crestor (rosuvastatin) and associated medicines in over 30 countries in Europe to Grünenthal GmbH (Grünenthal). Rights in the UK and Spain were not included in the agreement.
When to tell your doctor about Crestor side effects?
To make sure Crestor is safe for you, tell your doctor if you have ever had: liver disease; kidney disease; diabetes; a thyroid disorder; if you drink more than 2 alcoholic beverages daily; if you are of Asian descent; or if you are 65 or older.
How is the payment from Grunenthal to AstraZeneca reported?
Under the terms of the agreement, AstraZeneca received a payment of $320m from Grünenthal and may also be eligible for future milestone payments of up to $30m. The upfront payment will be reported in AstraZeneca’s financial statements within other operating income and expense in the first quarter of 2021.
When did the FDA update the warning information on Crestor?
FDA Updates Crestor Warning Information. March 3, 2005 — The FDA has issued a public health advisory to further explain the risks and benefits of the cholesterol-lowering drug Crestor. The drug will now carry a new label that includes new recommended doses for patients at a higher risk of muscle damage, including Asian patients.
What do you need to know about Crestor tablets?
CRESTOR (rosuvastatin calcium) TABLETS DESCRIPTION CRESTORfi(rosuvastatin calcium) is a synthetic lipid-lowering agent. Rosuvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.
What are the inactive ingredients in Crestor tablets?
CRESTOR Tablets for oral administration contain 5, 10, 20, or 40 mg of rosuvastatin and the following inactive ingredients: microcrystalline cellulose NF, lactose monohydrate NF, tribasic calcium phosphate NF, crospovidone NF, magnesium stearate NF, hypromellose NF, triacetin NF, titanium dioxide USP, yellow ferric oxide, and red ferric oxide NF.
What kind of muscle damage can Crestor cause?
The FDA is providing up-to-date information about the risk of serious muscle damage – called rhabdomyolysis — in patients taking Crestor as well as similar drugs, called statins. This is a well-known, rare side effect of all statins, it says. Rhabdomyolysis is a condition in which muscle cells break down.