Can aspartame cause high liver enzymes?

Can aspartame cause high liver enzymes?

Chronic administration of aspartame increased plasma alanine aminotransferase (ALT) and aspartate aminotransferase activities and caused liver injury as well as marked decreased hepatic levels of reduced glutathione (GSH), oxidized glutathione (GSSG), γ-glutamylcysteine ​​(γ-GC), and most metabolites of the trans- …

Does aspartame cause liver disease?

Aspartame may act as a chemical stressor to alter the functional status of liver which leading to the hepatotoxicity. Long-term aspartame consumption may alter redox status of liver and its metabolite methanol could induce hepatotoxicity via apoptosis.

Is phenylalanine bad for liver?

Phenylalanine is thought to mediate or exacerbate hepatic encephalopathy, and an impaired liver may not be able to cope with the ammoniagenic properties of the amino acid constituents, or adequately metabolize methanol.

Can artificial sweeteners cause liver problems?

Artificial sweeteners are related to non-alcoholic fatty liver disease: Microbiota dysbiosis as a novel potential mechanism.

How does aspartame affect the liver long term?

Effects on Liver A study published in “Food and Chemical Toxicology” in 2011 found that long-term aspartame consumption may change the antioxidant status of the liver 2. Rats given doses of aspartame-laced water over a period of time had lower levels of glutathione, a chemical that helps the body use antioxidants to fight free radicals.

How are aspartame and phenylalanine produced in the body?

Both are naturally occurring amino acids. Aspartic acid is produced by your body, and phenylalanine is an essential amino acid that you get from food. When your body processes aspartame, part of it is broken down into methanol. Consumption of fruit, fruit juice, fermented beverages, and some vegetables also contain or result in methanol production.

What foods can cause a build up of phenylalanine?

Without the enzyme necessary to process phenylalanine, a dangerous buildup can develop when a person with PKU eats foods that contain protein or eats aspartame, an artificial sweetener.

What happens if you have high phenylalanine levels?

The enzyme needed to convert phenylalanine is missing or severely reduced, resulting in high levels of phenylalanine and severe brain damage. Less severe forms of PKU. In mild or moderate forms, the enzyme retains some function, so phenylalanine levels are not as high, resulting in a smaller risk of significant brain damage.

Can you have aspartame if you have phenylalanine?

This warning helps people with PKU avoid products that are a source of phenylalanine. If you don’t have PKU, you probably don’t need to worry about harmful health effects of phenylalanine — with certain important exceptions. Aspartame in large doses can cause a rapid increase in brain levels of phenylalanine.

Is there a connection between aspartame and liver enzymes?

But it seems there is a very serious connection between Aspartame consumption and elevated liver enzymes reflected in GGT levels in blood test.

Is it safe to eat foods that contain aspartame?

Should you find that you experience adverse effects after eating foods that contain aspartame, simply avoid eating these foods, recommends the Center for Science in the Public Interest. Unless you have PKU, don’t avoid phenylalanine because it is an essential amino acid you need to stay healthy.

What foods should you avoid if you have phenylalanine in them?

Federal regulations require that any food that contains aspartame bear this warning: “Phenylketonurics: Contains phenylalanine.”. This warning helps people with PKU avoid products that are a source of phenylalanine.