Are there any side effects for taking spironolactone?
Are there any side effects for taking spironolactone?
Spironolactone (“Spiro”) is a potassium-sparing diuretic and steroid drug frequently prescribed in the US to assigned-male-at-birth (AMAB) trans women as part of their HRT. However, the drug has a number of mild to severe mental side effects, can lead to bodily changes which most trans women might consider…
Is there a link between gynecomastia and spironolactone?
Plasma concentrations of the various hormones did not change as a result of either spironolactone or the development of gynecomastia. Inhibition of testosterone synthesis or alteration in its metabolic clearance by spironolactone does not appear to be the cause of spironolactone‐induced gynecomastia in man.
What is the effect of spironolactone on heart failure?
In addition, as an aldosterone antagonist, spironolactone is considered a neuroendocrine modulator (aldosterone receptor blocker). One human study reported that low-dose spironolactone (subdi -uretic doses) reduced heart failure mortality by approximately 18–40% and this effect was attributable to its neuroendocrine modulatory effects.
What can spironolactone be used for in trans patients?
Its sole use in trans patients is to reduce the effect of testosterone, and also testosterone levels, a job that estradiol would do if a suitable estradiol-only regimen were used instead.
What are the long term side effects of spironolactone?
Side effects requiring immediate medical attention 1 Bleeding gums 2 bloody or black, tarry stools 3 bloody urine 4 blurred vision 5 breast pain 6 chest pain 7 clay-colored stools 8 clear or bloody discharge from the nipple 9 cloudy urine 10 confusion
Are there any side effects of radiation therapy for meningioma?
The most common side effects of radiation therapy for meningioma include: Aside from cognitive changes, which can become permanent, most of these side effects are temporary and usually go away within several weeks after the completion of treatment. In the meantime, most side effects can be managed with medications and lifestyle changes.
How does taking spironolactone affect testosterone levels?
“Suppression of plasma testosterone levels from a mean of 760 ng/dl… in normal young adult men… to 123 ng/dl was noted 36 h after estradiol administration.”(2) The second effect: taking Spiro, for reasons that are not well understood, appears to interfere with the patient achieving expected blood levels of estradiol.
Is it safe to take spironolactone with eplerenone?
You should not use spironolactone if you are allergic to it, or if you have: Addison’s disease (an adrenal gland disorder); high levels of potassium in your blood (hyperkalemia); if you are unable to urinate; or. if you are also taking eplerenone.