Why is it called smoldering myeloma?

Why is it called smoldering myeloma?

The only signs of smoldering myeloma are an elevation of plasma cells (in the bone marrow) and a high level of a type of protein called M protein that shows up in lab tests in the urine and blood. The reason the disorder is referred to as “smoldering” is that it often worsens slowly over time.

What is the criteria for smoldering myeloma?

To meet the definition of smoldering multiple myeloma, both of the following criteria must be met: Serum monoclonal protein (IgG or IgA) ≥30 g/L or urinary monoclonal protein ≥500 mg per 24 h and/or clonal bone marrow plasma cells 10–60% Absence of myeloma-defining events or amyloidosis.

What is a Smouldering myeloma?

Smouldering myeloma (also sometimes known as asymptomatic myeloma) is an early form of myeloma which usually progresses to active myeloma, but at a slow rate. In smouldering myeloma abnormal cells can be detected in the bone marrow, and abnormal protein can be detected in the blood and/or urine.

How fast does smoldering myeloma progress?

Smoldering myeloma is a precancerous condition that alters certain proteins in blood and/or increases plasma cells in bone marrow, but it does not cause symptoms of disease. About half of those diagnosed with the condition, however, will develop multiple myeloma within 5 years.

How long can you have Smouldering myeloma?

Is there such a thing as smoldering multiple myeloma?

Smoldering multiple myeloma. Smoldering multiple myeloma (SMM) is an early precursor to a rare blood cancer known as multiple myeloma, which affects plasma cells. This type of cancer produces certain proteins that can be measured in both blood and urine. These proteins show up before a person has any symptoms of cancer.

When to start clinical trials for smoldering myeloma?

And some who are high risk of developing myeloma should participate in clinical trials while others could wait years longer until they are treated. Smoldering myeloma has a 10% per year risk of progression during the first 5 years after diagnosis. This risk decreases to 3% per year over the next 5 years and is 1% per year 10 years after diagnosis.

Which is an early precursor to multiple myeloma?

Smoldering multiple myeloma (SMM) is an early precursor to a rare blood cancer known as multiple myeloma, which affects plasma cells. This type of cancer produces certain proteins that can be measured in both blood and urine.

What happens to your blood if you have multiple myeloma?

But it may get worse and become multiple myeloma, which is cancer. Smoldering multiple myeloma causes these changes: Levels of monoclonal protein (M protein) in your blood that are 3 milligrams or higher Levels of plasma cells in your bone marrow, where your red blood cells are made, that are 10% or higher