Why does caffeine have different effects on people?

Why does caffeine have different effects on people?

Each person’s adenosine receptors are different due to genetics, and caffeine might not bind well with them. The CYP1A2 enzymes are the ones that metabolize caffeine, and some people produce less of the one that knocks out caffeine quickly (the CYP1A2*1F (rs762551) enzyme, to be exact).

Why does caffeine have a negative effect on me?

If you already have anxiety or high levels of stress, caffeine can worsen the symptoms you’re already experiencing. For example, caffeine can promote panic attacks, loss of sleep, and worsened anxiety symptoms in those with anxiety disorders, according to the Anxiety and Depression Association of America.

Do some people react differently to caffeine?

Some will metabolise caffeine quickly, while others will metabolise it more slowly; some will show greater sensitivity to the stimulating effects of caffeine, while others needs higher amounts to feel an effect1.

What are the effects of caffeine on the body?

Caffeine may affect the way the body absorbs calcium, and this has raised concerns that drinking coffee can lead to osteoporosis. However, this has not been confirmed by research.

Why does coffee affect me more than others?

The stimulating effects of caffeine in the body are short in duration. A fast-metaboliser may drink multiple cups of coffee a day. Slow-metabolisers metabolise caffeine more slowly, so caffeine will be present in the body and brain for a longer period of time.

Why does caffeine make you feel alert when you drink coffee?

Due to its similar structure, caffeine may bind to the adenosine receptors, acting as an imposter and blocking the actions of adenosine, leading to feelings of alertness 70. For further explanation, watch this video on coffee and its effect on the brain.

Is there a link between caffeine and depression?

The consumption of decaffeinated coffee had no impact on depression risk. This observational study suggests the possibility of a protective effect of caffeine on depression risk 31. A cohort study of Finnish men reported a 77% risk reduction for depression in heavy coffee drinkers (those who consumed over 813mg caffeine daily).