What is the most powerful stimulator of stomach acid secretion?

What is the most powerful stimulator of stomach acid secretion?

Gastrin acts on parietal cells directly and indirectly too, by stimulating the release of histamine. The release of histamine is the most important positive regulation mechanism of the secretion of gastric acid in the stomach. Its release is stimulated by gastrin and acetylcholine and inhibited by somatostatin.

What is a potent stimulant for acid secretion?

Gastrin is the most potent endogenous stimulant for gastric acid secretion by favoring synthesis and release of histamine from ECL cells.

Does histamine stimulate gastric acid secretion?

The fact that histamine H2-receptor antagonists strongly inhibit basal and nocturnal gastric secretion and acid secretion stimulated by histamine, pentagastrin, caffeine, insulin, sham feeding and food indicate that histamine plays a physiological role in gastric acid secretion.

How do you reduce stomach acid production?

Examples of H2 antagonists commonly used to suppress gastric acid secretion include cimetidine (Tagamet HB), ranitidine (Zantac 75), famotidine (Pepcid AC) and nizatidine (Axid AR). These drugs, particularly cimetidine, are among the most widely prescribed drugs in man.

How do you control gastric acid secretion?

Which is the major stimulant of stomach acid secretion?

Gastrin, secreted from G cells, stimulates the release of histamine from ECL cells, which is the major stimulant of acid from gastric parietal cells. Somatostatin, acting through sst 2, inhibits secretion from each of these cell types, although the predominant actions seem to be on ECL and parietal cells.

How are acetylcholine, gastrin and histamine involved in gastric acid secretion?

The three stimulants of gastric acid secretion likely to have physiological roles in regulation of secretion are acetylcholine, gastrin, and histamine. Acetylcholine is released by vagal and intramucosal reflex stimulation, acting directly on the parietal cell. Gastrin is released by peptides and fr … Regulation of gastric acid secretion

How does stomach acid secretion occur in the parietal cells?

Overview: Three stimuli directly induce stomach acid secretion by parietal cells. Acetylcholine:Acetylcholineis released by parasympatheticfibers in vagus nerve efferents which synapse directly onto parietal cells Histamine:Histamine is released by enterochromaffin-like cells (ECLs) which lie directly adjacent to parietal cells in the oxyntic gland

How is acetylcholine released in the digestive system?

Acetylcholine is released by vagal and intramucosal reflex stimulation, acting directly on the parietal cell. Gastrin is released by peptides and free amino acids in the stomach and is the only known hormonal stimulant of acid secretion.