What is anti b2 glycoprotein?
What is anti b2 glycoprotein?
Anti-beta-2-glycoproteins (anti-B2GP1 antibodies, anti-beta-2-glycoprotein antibodies) are antibodies produced by an individual’s immune system against his or her own phospholipids. These phospholipids are found on the surface of the platelets responsible for blood clotting (clot formation).
What does beta-2-glycoprotein do?
Beta-2-glycoprotein I, also known as apolipoprotein H, inhibits the intrinsic coagulation pathway and is involved in the regulation of blood coagulation. Beta-2-glycoprotein I has been shown to be the primary autoantigen for anti-cardiolipin antibodies.
What does a positive beta-2 glycoprotein 1 antibody test mean?
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
What is the likelihood of having a positive b2gp1 antibody?
Because lots of people are tested with other clinical syndromes, the overall likelihood of having APS with a positive B2GP1 antibody is approximately 32% (i.e. the majority of the patients will have been tested erroneously and will not have APS).
What are the side effects of beta 2 glycoprotein 1 IgM?
Antiphospholipid syndrome (APS) patients portray abnormal levels of beta-2 GP1 IgM antibodies in the blood. APS causes the development of inappropriate blood clots, low platelet count and can trigger a very unhealthy pregnancy with complications such as repeated miscarriages and preeclampsia. Some of the health problems caused by APS are:
Can a beta 2 GP1 antibody be detected by an anticoagulant?
Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment. The immunoassay for beta-2 glycoprotein 1 (beta 2 GP1) antibodies does not distinguish between autoantibodies and antibodies produced in response to infectious agents or as epiphenomena following thrombosis.
A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.
Antiphospholipid syndrome (APS) patients portray abnormal levels of beta-2 GP1 IgM antibodies in the blood. APS causes the development of inappropriate blood clots, low platelet count and can trigger a very unhealthy pregnancy with complications such as repeated miscarriages and preeclampsia. Some of the health problems caused by APS are:
Detection of beta-2 GP1 antibodies is not affected by anticoagulant treatment. The immunoassay for beta-2 glycoprotein 1 (beta 2 GP1) antibodies does not distinguish between autoantibodies and antibodies produced in response to infectious agents or as epiphenomena following thrombosis.
Where does Beta 2 glycoprotein 1 come from?
Beta-2 glycoprotein 1 (beta-2 GP1, also called apolipoprotein H) is a 326-amino acid polypeptide synthesized by hepatocytes, endothelial cells, and trophoblast cells.