What hormone secretion abnormality causes the following conditions gigantism gigantism?

What hormone secretion abnormality causes the following conditions gigantism gigantism?

Gigantism is a rare condition due to abnormal, accelerated growth caused by excessive amounts of growth hormone secretion during childhood or adolescence. It is almost always the result of a growth hormone-secreting pituitary tumour.

Why does excess secretion of growth hormone in childhood produce gigantism?

If excessive production of growth hormone starts in childhood before the growth plates of the bones (the area at the ends of bones from which bone growth occurs) have closed, the condition causes gigantism. The long bones grow enormously. A person grows to unusually great stature, and the arms and legs lengthen.

What is the treatment for gigantism?

Surgery. Removing the tumor is the preferred treatment for gigantism if it’s the underlying cause. The surgeon will reach the tumor by making an incision in your child’s nose. Microscopes or small cameras may be used to help the surgeon see the tumor in the gland.

What will happen to a person with excessive secretion of hormones?

In adults, excessive growth hormone for a long period of time produces a condition known as acromegaly, in which patients have swelling of the hands and feet and altered facial features. These patients also have organ enlargement and serious functional disorders such as high blood pressure, diabetes and heart disease.

What happens when there is too much growth hormone?

People can also have too much growth hormone. Usually the cause is a pituitary gland tumor, which is not cancer. Too much growth hormone can cause gigantism in children, where their bones and their body grow too much. In adults, it can cause acromegaly, which makes the hands, feet and face larger than normal.

What gland is affected by gigantism?

Gigantism is a serious condition that is nearly always caused by an adenoma, a tumor of the pituitary gland. Gigantism occurs in patients who had excessive growth hormone in childhood. The pituitary tumor cells secrete too much growth hormone (GH), leading to many changes in the body.

What is the treatment of gigantism?

Your doctor may use the drugs octreotide or lanreotide to prevent the growth hormone’s release. These drugs mimic another hormone that stops growth hormone production. They’re usually given as an injection about once a month. Bromocriptine and cabergoline are drugs that can be used to lower growth hormone levels.

When does excessive production of growth hormone cause gigantism?

If excessive production of growth hormone starts in childhood before the growth plates of the bones (the area at the ends of bones from which bone growth occurs) have closed, the condition causes gigantism.

What causes acromegaly and what causes gigantism?

Acromegaly is also caused by excess growth hormone secretion however, this happens during adulthood rather than childhood. This means that height is normal as the growth plates have fused before the excess growth hormone secretion occurs. What causes gigantism?

Is there an etiology for pituitary gigantism?

Although the etiology of sporadic gigantism is often unknown, a number of germline and somatic mutations in genes associated with syndromic and familial growth hormone hypersecretion have been reported in children and adolescents with pituitary gigantism 15).

How does gigantism affect the growth of bones?

It is the growth hormone that triggers the secretion of IGF which is essential for normal growth of tissues and bones. But in children with gigantism abnormal amounts of growth factor is produced causing enlarged growth in bones and tissues.

What causes the overproduction of growth hormone in gigantism?

Gigantism is characterized by an excess of growth hormone (GH). This overproduction of growth hormone that brings about gigantism is virtually always caused by pituitary growths (adenomas).

Acromegaly is also caused by excess growth hormone secretion however, this happens during adulthood rather than childhood. This means that height is normal as the growth plates have fused before the excess growth hormone secretion occurs. What causes gigantism?

When does gigantism occur in the human body?

Gigantism is a rare endocrine disorder caused by unusually high growth hormone levels found during childhood and adolescence before the growth plates in the bones have closed.

Although the etiology of sporadic gigantism is often unknown, a number of germline and somatic mutations in genes associated with syndromic and familial growth hormone hypersecretion have been reported in children and adolescents with pituitary gigantism 15).