What gene causes Graves disease?
What gene causes Graves disease?
Various genes have been identified that are linked to Graves’ disease including genes that weaken or modify the response of the immune system (immunomodulators) such as the CD25, CD40, CD40, CTLA-4, FOXP3, and various HLA genes, particularly HLA-DR3.
Is there a genetic marker for Graves disease?
HLA-DRB1 and HLA-DQB1 also appear to be associated with Graves disease susceptibility. Genetic factors contribute approximately 20-30% of overall disease susceptibility.
Is hyperthyroidism a genetic trait?
Thyroid disease is often hereditary “More than 75% of the time, patients with thyroid disease tell me that someone on one side of their family has thyroid disease,” says Dr. Nasr. “The more family members that have thyroid disease, the greater the likelihood that there is a hereditary root.
Which is the gene that causes Graves disease?
The cytotoxic T-lymphocyte–associated-4 (CTLA-4) gene, which confers a relative risk for the development of Graves’ disease of around 2.0, provides a useful example of the numbers required.
What does Graves disease do to the thyroid?
Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions.
Why is Graves disease more common in women?
Graves disease affects about 1 in 200 people. The disease occurs more often in women than in men, which may be related to hormonal factors. Graves disease is the most common cause of thyroid overactivity (hyperthyroidism) in the United States. Graves disease is thought to result from a combination of genetic and environmental factors.
What does MHC-HLA stand for in Graves disease?
POPULATION-BASED, CASE-CONTROL STUDY ASSOCIATIONS BETWEEN THE MHC-HLA REGION ON CHROMOSOME 6p21 AND GRAVES’ DISEASE (SINCE 1990) MHC-HLA = major histocompatibility complex–human leukocyte antigen.
What kind of disease is graves’disease?
Graves’ disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).
Is there a genetic susceptibility to Graves disease?
Although the MHC-HLA region and the CTLA-4 gene undoubtedly contribute to the genetic susceptibility to Graves’ disease, even the best estimates from the United Kingdom leave up to 50% of familial clustering unexplained.45 Furthermore, no reproducible evidence supports a specific Graves’ disease susceptibility locus.
What causes the overproduction of thyroid hormones Graves disease?
Graves’ disease is an immune system disorder that results in the overproduction of thyroid hormones (hyperthyroidism). Although a number of disorders may result in hyperthyroidism, Graves’ disease is a common cause. Thyroid hormones affect many body systems, so signs and symptoms of Graves’ disease can be wide ranging.
How does the autoimmune Registry help Graves disease?
The Autoimmune Registry supports research for Graves disease by collecting information about patients with this and other autoimmune diseases. You can join the registry to share your information with researchers and receive updates about participating in new research studies.