What causes metastatic calcification?
What causes metastatic calcification?
Metastatic calcification is caused by an increased calcium phosphate product in the blood, and may result from hypercalcemia or hyperphosphatemia, or both. It is commonly associated with hyperparathyroidism, sarcoidosis, metastatic disease, and myeloma (Fig. 8-36).
What is true metastatic calcification?
The mechanism of calcification in the viscera is categorized into two groups. Metastatic calcification with hypercalcemia occurs when calcium deposits in previously normal tissue whereas dystrophic calcification occurs in previously damaged tissue.
What is metastatic calcification of the soft tissues?
When soft-tissue calcification occurs with an elevated serum calcium-phosphorus ion product, it is known as metastatic calcification. In these cases, amorphous calcium phosphate and calcium hydroxyapatite crystals are deposited in multiple locations including the visceral organs (5).
What is metastatic mineralization?
Metastatic mineralization, also known as metastatic calcification, is a form of pathologic calcification that occurs in previously healthy tissues, and is generally associated with a disturbance in calcium and phosphorus metabolism, particularly calcium and phosphorus excess with extracellular deposition of amorphous …
Which organ is metastatic calcification typically associated with?
Typical locations for metastatic calcification include the lungs (metastatic pulmonary calcification) and kidneys but the condition can also occur in the liver and heart.
Can microcalcifications be metastatic?
To our knowledge, no case of metastatic primary peritoneal serous carcinoma with abnormal breast microcalcifications as the only imaging finding has been reported previously. In patients with newly diagnosed ovarian or peritoneal cancer, breast metastasis is not an uncommon finding.
What is the mechanism of metastatic calcification?
The exact mechanism for metastatic calcification is not known; however, it may be influenced by serum calcium and phosphate concentrations, alkaline phosphatase activity, and local physicochemical conditions such as pH. 49 In contrast to the process of dystrophic calcification, metastatic calcification does not require a previous tissue injury. 46
Which is better for stone formation acidic or alkaline?
An alkaline pH favors the crystallization of calcium- and phosphate-containing stones, whereas and acidic urine pH promotes uric acid or cystine stones.
How is the alkaline internal component susceptible to calcification?
It turns out that all of these tissues excrete acid, and therefore have an alkaline internal component, which is susceptible to calcification. You can see either amorphous deposits or discrete crystals, just like in dystrophic calcification. The deposits are formed of calcium phosphate crystals too, just like in dystrophic calcification.
What is the link between the alkaline diet and cancer?
What is the link between the alkaline diet and cancer? Some studies have shown that acidic environments help cancer cells grow. So the idea is that a diet high in alkaline foods (high pH) and low in acidic foods will raise the body’s pH levels (make the body more alkaline) and prevent or even cure cancer.
Which is the most alkaline pH in the body?
So… let’s dive into this. Do you recall chemistry? Acidity and Alkalanity are measured using the PH scale which is 0-14; 0 being highly acidic, 7 is neutral, and 14 is the most alkaline (or “basic”).
How does the pH of a food affect its alkalinity?
One way diet affects your health is through a process called “acid-alkaline balance.” The pH (potential of hydrogen) determines a substance’s acidity or alkalinity and is measured on a scale of 0 to 14. The lower the pH the more acidic the solution. The higher the pH the more alkaline (or base) the solution.
Which is more acidic 3 or 4 in the pH scale?
The pH scale is also logarithmic, which means for example that a pH of 3 is 10 times more acidic than a pH of 4, and a pH of 8 is ten times more alkaline/basic than a pH of 7. The myth that we need to “alkalize” our bodies is based on a fundamental misunderstanding of human physiology. Each section of our body has its special highly controlled pH.
Which is more alkaline, 7 or 3?
Acidity and Alkalanity are measured using the PH scale which is 0-14; 0 being highly acidic, 7 is neutral, and 14 is the most alkaline (or “basic”). The pH scale is also logarithmic, which means for example that a pH of 3 is 10 times more acidic than a pH of 4, and a pH of 8 is ten times more alkaline/basic than a pH of 7.