How toxic is sulfasalazine?

How toxic is sulfasalazine?

Sulphasalazine has clinically important side-effects in up to one-fifth of patients but these are mostly nausea and vomiting, skin rashes, arthralgia, fever and hepatic dysfunction. More serious side-effects include pulmonary toxicity and blood dyscrasias.

What happens if you take too much sulfasalazine?

What happens if I overdose on Sulfasalazine (Azulfidine)? Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure.

Is sulfasalazine safer than methotrexate?

Sulfasalazine. Sulfasalazine (Azulfidine®) is an effective DMARD for the treatment of RA. Its effectiveness overall is somewhat less than that methotrexate, but it has been shown to reduce signs and symptoms and slow radiographic damage.

Why is it hard to get sulfasalazine?

Reason for the Shortage Pfizer states the shortage is due to manufacturing delay. Azulfidine Entabs 500 mg in 300 count bottles have an updated NDC number.

Are there any side effects to taking sulfasalazine?

This medication does not cure this condition, but it helps decrease symptoms such as fever, stomach pain, diarrhea, and rectal bleeding. After an attack is treated, sulfasalazine is also used to increase the amount of time between attacks.

Can you take sulfasalazine if you have ulcerative colitis?

Sulfasalazine will not cure ulcerative colitis, but it can reduce the number of attacks you have. Sulfasalazine is also used to treat rheumatoid arthritis in children and adults who have used other arthritis medicines that did not work or have stopped working.

Are there any other drugs that are similar to sulfasalazine?

Other drugs may affect sulfasalazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What is the role of sulfasalazine in the body?

It has a role as a non-steroidal anti-inflammatory drug, an antiinfective agent, a gastrointestinal drug, an EC ( glutathione transferase) inhibitor and a drug allergen. It is a sulfonamide, a member of pyridines and a member of azobenzenes. It derives from a sulfanilamide.